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Lipoprotein Particle Size Distribution

When a person has smaller size LDL-cholesterol, many more particles are needed to carry the same amount of cholesterol in the blood stream.  This increased number of particles may interfere with efficient removal of LDL-cholesterol from the bloodstream by the liver. 

LDL Pattern B is defined as a smaller, abnormal LDL-cholesterol particle size distribution.  These abnormally small lipoprotein particles are more susceptible to oxidation and are present in over 30% of adult men.  These pattern B particles can more easily penetrate the artery walls.

“...A markedly higher frequency of a functional CETP variant that led to increased particle sizes of HDL and LDL and thus a better health performance is the first example of a phenotype and an associated genotype in humans with exceptional longevity.”  Quote from "Biological evidence for inheritance of exceptional longevity", Mech Ageing Dev. 2005 Feb;126(2):341-5

Changes in an individual’s HDL and LDL Particle Size Profile may be present due to heredity and/or environmental stress factors, and cannot be detected by standard cholesterol testing.  Small changes in particle distribution which are the result of positive interventions can be accurately measured by the Longevity Test.

 


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